Week
1
Sunday 8:05 PM
September 7, 2025
@
17 - 13
Seattle
Seahawks
San Francisco 49ers Won! Record: 1-0
Week
2
Sunday 5:00 PM
September 14, 2025
@
26 - 21
New Orleans
Saints
San Francisco 49ers Won! Record: 2-0
Week
3
Sunday 8:25 PM
September 21, 2025
VS.
16 - 15
Arizona
Cardinals
San Francisco 49ers Won! Record: 3-0
Week
4
Sunday 8:05 PM
September 28, 2025
VS.
21 - 26
Jacksonville
Jaguars
San Francisco 49ers Lost. Record: 3-1
Week
5
Friday 12:15 AM
October 3, 2025
@
26 - 23
Los Angeles
Rams
San Francisco 49ers Won! Record: 4-1
Week
6
Sunday 8:25 PM
October 12, 2025
@
19 - 30
Tampa Bay
Buccaneers
San Francisco 49ers Lost. Record: 4-2
Week
7
Monday 12:20 AM
October 20, 2025
VS.
20 - 10
Atlanta
Falcons
San Francisco 49ers Won! Record: 5-2
Week
8
Sunday 5:00 PM
October 26, 2025
@
15 - 26
Houston
Texans
San Francisco 49ers Lost. Record: 5-3
Week
9
Sunday 6:00 PM
November 2, 2025
@
34 - 24
New York
Giants
San Francisco 49ers Won! Record: 6-3
Week
10
Sunday 9:25 PM
November 9, 2025
VS.
26 - 42
Los Angeles
Rams
San Francisco 49ers Lost. Record: 6-4
Week
11
Sunday 9:05 PM
November 16, 2025
@
41 - 22
Arizona
Cardinals
San Francisco 49ers Won! Record: 7-4
Week
12
Tuesday 1:15 AM
November 25, 2025
VS.
20 - 9
Carolina
Panthers
San Francisco 49ers Won! Record: 8-4
Week
13
Sunday 6:00 PM
November 30, 2025
@
26 - 8
Cleveland
Browns
San Francisco 49ers Won! Record: 9-4
Week
15
Sunday 9:25 PM
December 14, 2025
VS.
37 - 24
Tennessee
Titans
San Francisco 49ers Won! Record: 10-4
Week
16
Tuesday 1:15 AM
December 23, 2025
@
48 - 27
Indianapolis
Colts
San Francisco 49ers Won! Record: 11-4
Week
17
Monday 1:20 AM
December 29, 2025
VS.
42 - 38
Chicago
Bears
San Francisco 49ers Won! Record: 12-4
Week
18
Sunday 1:00 AM
January 4, 2026
VS.
3 - 13
Seattle
Seahawks
San Francisco 49ers Lost. Record: 12-5