Week
1
Sunday 5:00 PM
September 7, 2025
VS.
33 - 8
Miami
Dolphins
Indianapolis Colts Won! Record: 1-0
Week
2
Sunday 8:05 PM
September 14, 2025
VS.
29 - 28
Denver
Broncos
Indianapolis Colts Won! Record: 2-0
Week
3
Sunday 5:00 PM
September 21, 2025
@
41 - 20
Tennessee
Titans
Indianapolis Colts Won! Record: 3-0
Week
4
Sunday 8:05 PM
September 28, 2025
@
20 - 27
Los Angeles
Rams
Indianapolis Colts Lost. Record: 3-1
Week
5
Sunday 5:00 PM
October 5, 2025
VS.
40 - 6
Las Vegas
Raiders
Indianapolis Colts Won! Record: 4-1
Week
6
Sunday 5:00 PM
October 12, 2025
VS.
31 - 27
Arizona
Cardinals
Indianapolis Colts Won! Record: 5-1
Week
7
Sunday 8:05 PM
October 19, 2025
@
38 - 24
Los Angeles
Chargers
Indianapolis Colts Won! Record: 6-1
Week
8
Sunday 8:25 PM
October 26, 2025
VS.
38 - 14
Tennessee
Titans
Indianapolis Colts Won! Record: 7-1
Week
9
Sunday 6:00 PM
November 2, 2025
@
20 - 27
Pittsburgh
Steelers
Indianapolis Colts Lost. Record: 7-2
Week
10
Sunday 2:30 PM
November 9, 2025
VS.
31 - 25
Atlanta
Falcons
Indianapolis Colts Won! Record: 8-2
Week
12
Sunday 6:00 PM
November 23, 2025
@
20 - 23
Kansas City
Chiefs
Indianapolis Colts Lost. Record: 8-3
Week
13
Sunday 6:00 PM
November 30, 2025
VS.
16 - 20
Houston
Texans
Indianapolis Colts Lost. Record: 8-4
Week
14
Sunday 6:00 PM
December 7, 2025
@
19 - 36
Jacksonville
Jaguars
Indianapolis Colts Lost. Record: 8-5
Week
15
Sunday 9:25 PM
December 14, 2025
@
16 - 18
Seattle
Seahawks
Indianapolis Colts Lost. Record: 8-6
Week
16
Tuesday 1:15 AM
December 23, 2025
VS.
27 - 48
San Francisco
49ers
Indianapolis Colts Lost. Record: 8-7
Week
17
Sunday 6:00 PM
December 28, 2025
VS.
17 - 23
Jacksonville
Jaguars
Indianapolis Colts Lost. Record: 8-8
Week
18
Sunday 6:00 PM
January 4, 2026
@
30 - 38
Houston
Texans
Indianapolis Colts Lost. Record: 8-9