Week 1
September 8, 2025
Monday 12:20 AM
Baltimore Ravens
Vs.
41 - 40
Buffalo Bills Won! Record: 1-0
Week 2
September 14, 2025
Sunday 5:00 PM
New York Jets
At.
30 - 10
Buffalo Bills Won! Record: 2-0
Week 3
September 19, 2025
Friday 12:15 AM
Miami Dolphins
Vs.
31 - 21
Buffalo Bills Won! Record: 3-0
Week 4
September 28, 2025
Sunday 5:00 PM
New Orleans Saints
Vs.
31 - 19
Buffalo Bills Won! Record: 4-0
Week 5
October 6, 2025
Monday 12:20 AM
New England Patriots
Vs.
20 - 23
Buffalo Bills Lost. Record: 4-1
Week 6
October 13, 2025
Monday 11:15 PM
Atlanta Falcons
At.
14 - 24
Buffalo Bills Lost. Record: 4-2
Week 8
October 26, 2025
Sunday 5:00 PM
Carolina Panthers
At.
40 - 9
Buffalo Bills Won! Record: 5-2
Week 9
November 2, 2025
Sunday 9:25 PM
Kansas City Chiefs
Vs.
28 - 21
Buffalo Bills Won! Record: 6-2
Week 10
November 9, 2025
Sunday 6:00 PM
Miami Dolphins
At.
13 - 30
Buffalo Bills Lost. Record: 6-3
Week 11
November 16, 2025
Sunday 6:00 PM
Tampa Bay Buccaneers
Vs.
44 - 32
Buffalo Bills Won! Record: 7-3
Week 12
November 21, 2025
Friday 1:15 AM
Houston Texans
At.
19 - 23
Buffalo Bills Lost. Record: 7-4
Week 13
November 30, 2025
Sunday 9:25 PM
Pittsburgh Steelers
At.
26 - 7
Buffalo Bills Won! Record: 8-4
Week 14
December 7, 2025
Sunday 6:00 PM
Cincinnati Bengals
Vs.
39 - 34
Buffalo Bills Won! Record: 9-4
Week 15
December 14, 2025
Sunday 6:00 PM
New England Patriots
At.
35 - 31
Buffalo Bills Won! Record: 10-4
Week 16
December 21, 2025
Sunday 6:00 PM
Cleveland Browns
At.
23 - 20
Buffalo Bills Won! Record: 11-4
Week 17
December 28, 2025
Sunday 9:25 PM
Philadelphia Eagles
Vs.
12 - 13
Buffalo Bills Lost. Record: 11-5
Week 18
January 4, 2026
Sunday 9:25 PM
New York Jets
Vs.
35 - 8
Buffalo Bills Won! Record: 12-5