Week 1
September 7, 2025
Sunday 8:05 PM
Seattle Seahawks
At.
17 - 13
San Francisco 49ers Won! Record: 1-0
Week 2
September 14, 2025
Sunday 5:00 PM
New Orleans Saints
At.
26 - 21
San Francisco 49ers Won! Record: 2-0
Week 3
September 21, 2025
Sunday 8:25 PM
Arizona Cardinals
Vs.
16 - 15
San Francisco 49ers Won! Record: 3-0
Week 4
September 28, 2025
Sunday 8:05 PM
Jacksonville Jaguars
Vs.
21 - 26
San Francisco 49ers Lost. Record: 3-1
Week 5
October 3, 2025
Friday 12:15 AM
Los Angeles Rams
At.
26 - 23
San Francisco 49ers Won! Record: 4-1
Week 6
October 12, 2025
Sunday 8:25 PM
Tampa Bay Buccaneers
At.
19 - 30
San Francisco 49ers Lost. Record: 4-2
Week 7
October 20, 2025
Monday 12:20 AM
Atlanta Falcons
Vs.
20 - 10
San Francisco 49ers Won! Record: 5-2
Week 8
October 26, 2025
Sunday 5:00 PM
Houston Texans
At.
15 - 26
San Francisco 49ers Lost. Record: 5-3
Week 9
November 2, 2025
Sunday 6:00 PM
New York Giants
At.
34 - 24
San Francisco 49ers Won! Record: 6-3
Week 10
November 9, 2025
Sunday 9:25 PM
Los Angeles Rams
Vs.
26 - 42
San Francisco 49ers Lost. Record: 6-4
Week 11
November 16, 2025
Sunday 9:05 PM
Arizona Cardinals
At.
41 - 22
San Francisco 49ers Won! Record: 7-4
Week 12
November 25, 2025
Tuesday 1:15 AM
Carolina Panthers
Vs.
20 - 9
San Francisco 49ers Won! Record: 8-4
Week 13
November 30, 2025
Sunday 6:00 PM
Cleveland Browns
At.
26 - 8
San Francisco 49ers Won! Record: 9-4
Week 15
December 14, 2025
Sunday 9:25 PM
Tennessee Titans
Vs.
37 - 24
San Francisco 49ers Won! Record: 10-4
Week 16
December 23, 2025
Tuesday 1:15 AM
Indianapolis Colts
At.
48 - 27
San Francisco 49ers Won! Record: 11-4
Week 17
December 29, 2025
Monday 1:20 AM
Chicago Bears
Vs.
42 - 38
San Francisco 49ers Won! Record: 12-4
Week 18
January 4, 2026
Sunday 1:00 AM
Seattle Seahawks
Vs.
3 - 13
San Francisco 49ers Lost. Record: 12-5