Week 1
September 7, 2025
Sunday 5:00 PM
Miami Dolphins
Vs.
33 - 8
Indianapolis Colts Won! Record: 1-0
Week 2
September 14, 2025
Sunday 8:05 PM
Denver Broncos
Vs.
29 - 28
Indianapolis Colts Won! Record: 2-0
Week 3
September 21, 2025
Sunday 5:00 PM
Tennessee Titans
At.
41 - 20
Indianapolis Colts Won! Record: 3-0
Week 4
September 28, 2025
Sunday 8:05 PM
Los Angeles Rams
At.
20 - 27
Indianapolis Colts Lost. Record: 3-1
Week 5
October 5, 2025
Sunday 5:00 PM
Las Vegas Raiders
Vs.
40 - 6
Indianapolis Colts Won! Record: 4-1
Week 6
October 12, 2025
Sunday 5:00 PM
Arizona Cardinals
Vs.
31 - 27
Indianapolis Colts Won! Record: 5-1
Week 7
October 19, 2025
Sunday 8:05 PM
Los Angeles Chargers
At.
38 - 24
Indianapolis Colts Won! Record: 6-1
Week 8
October 26, 2025
Sunday 8:25 PM
Tennessee Titans
Vs.
38 - 14
Indianapolis Colts Won! Record: 7-1
Week 9
November 2, 2025
Sunday 6:00 PM
Pittsburgh Steelers
At.
20 - 27
Indianapolis Colts Lost. Record: 7-2
Week 10
November 9, 2025
Sunday 2:30 PM
Atlanta Falcons
Vs.
31 - 25
Indianapolis Colts Won! Record: 8-2
Week 12
November 23, 2025
Sunday 6:00 PM
Kansas City Chiefs
At.
20 - 23
Indianapolis Colts Lost. Record: 8-3
Week 13
November 30, 2025
Sunday 6:00 PM
Houston Texans
Vs.
16 - 20
Indianapolis Colts Lost. Record: 8-4
Week 14
December 7, 2025
Sunday 6:00 PM
Jacksonville Jaguars
At.
19 - 36
Indianapolis Colts Lost. Record: 8-5
Week 15
December 14, 2025
Sunday 9:25 PM
Seattle Seahawks
At.
16 - 18
Indianapolis Colts Lost. Record: 8-6
Week 16
December 23, 2025
Tuesday 1:15 AM
San Francisco 49ers
Vs.
27 - 48
Indianapolis Colts Lost. Record: 8-7
Week 17
December 28, 2025
Sunday 6:00 PM
Jacksonville Jaguars
Vs.
17 - 23
Indianapolis Colts Lost. Record: 8-8
Week 18
January 4, 2026
Sunday 6:00 PM
Houston Texans
At.
30 - 38
Indianapolis Colts Lost. Record: 8-9